This study, funded as part of the Robert Wood Johnson Foundation’s Systems for Action research program, tests the feasibility of an integrated system of medical, social and public health programming designed to improve outcomes for youth experiencing homelessness in Hennepin County, Minnesota. The study organizes community-engaged consensus building sessions with stakeholders from medical, social and public health systems and with youth experiencing homelessness in order to co-create strategies for system alignment, including multi-sector data integration, shared clinical practice guidelines, and co-location of health and social services for youth experiencing homelessness.