An applicant organization may submit more than one LOI as long as each LOI is distinct in terms of the study aims, scientific approach and research team. The Impact Award category is open only to applicants who have completed a pilot test or other type of preliminary research study and can provide documentation of results that confirm the feasibility of the proposed approach and its acceptability to key stakeholders within the relevant medical, social, and public health systems. Because of the small number of awards available under this CFP, it is unlikely that an applicant organization will receive multiple awards under this CFP.