Systems for Action (S4A) is a signature research program of the Robert Wood Johnson Foundation (RWJF) that builds a Culture of Health by rigorously testing new ways of connecting the nation’s fragmented medical, social, and public health systems. Health is shaped by a complex web of social, economic, and environmental conditions that extend far beyond the reach of the medical care system. S4A uses a wide research lens that includes and extends beyond the medical care and public health systems to incorporate social service systems such as housing, transportation, education, employment, food and nutrition assistance, child and family support, criminal and juvenile justice, and economic and community development. The national program office for the S4A program is based at the Department of Health Systems, Management and Policy at the Colorado School of Public Health, University of Colorado.